The AKR1B1 Antibody (CAB13944) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the AKR1B1 protein, this antibody allows for the detection and analysis of AKR1B1 expression in various cell types, making it an ideal choice for studies in metabolic diseases and cancer research.AKR1B1, also known as aldose reductase, plays a crucial role in cellular detoxification processes by reducing toxic aldehydes to their corresponding alcohols.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
AKR1B1 Antibody
SKU:
CAB13944
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
AR, ADR, ALR2, ALDR1, AKR1B1
Positive Sample:
HeLa, Jurkat, 293T, A375, HepG2, Mouse heart
Cellular Localization:
Cytoplasm.
Calculated MW:
36kDa
Observed MW:
36.5kDa
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.
Purification Method
Affinity purification
Gene ID
231
RRID
AB_2760797
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using AKR1B1 Rabbit pAb (CAB13944) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
