The ALDH8A1 Monoclonal Antibody (PAC015382) is a valuable tool for research involving ALDH8A1, an enzyme involved in the metabolism of aldehydes. This antibody, produced in mice, is highly specific to human samples and has been validated for use in multiple applications, including Western blot and immunohistochemistry.ALDH8A1 is a key player in the detoxification of aldehydes and is crucial for maintaining cellular health and homeostasis. Dysregulation of ALDH8A1 has been linked to various diseases, including metabolic disorders and cancer.
The ALDH8A1 Monoclonal Antibody binds specifically to the ALDH8A1 protein, enabling researchers to detect and study its expression in different cell types and tissues.By studying the role of ALDH8A1 in disease pathways, researchers can gain valuable insights into potential therapeutic targets and treatment strategies. The ALDH8A1 Monoclonal Antibody is a valuable tool for advancing research in the fields of metabolism, cancer biology, and drug development.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15382(ALDH8A1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse liver tissue, Mouse kidney tissue, Primary antibody: PACO15382(ALDH8A1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15382(ALDH8A1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid, biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene.
Synonyms:
aldehyde dehydrogenase 8 family, member A1
UniProt Protein Function:
ALDH8A1: Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro). Belongs to the aldehyde dehydrogenase family. 4 isoforms of the human protein are produced by alternative splicing.
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010]
