The ALDH8A1 Polyclonal Antibody (PAC015383) is a valuable tool for researchers studying ALDH8A1, an aldehyde dehydrogenase enzyme involved in the metabolism of aldehydes. This antibody, generated in rabbits, displays high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the ALDH8A1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for investigations in biochemistry and metabolic research.
ALDH8A1 plays a crucial role in the detoxification of aldehydes, serving as a protective mechanism against oxidative stress and metabolic imbalances. Researchers studying metabolic disorders, oxidative damage, and drug metabolism will find this antibody particularly useful in their investigations. By elucidating the function of ALDH8A1, scientists can gain insights into potential therapeutic targets for diseases related to abnormal aldehyde metabolism and oxidative stress.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15383(ALDH8A1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse liver tissue, Mouse kidney tissue, Primary antibody: PACO15383(ALDH8A1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15383(ALDH8A1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid, biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene.
Synonyms:
aldehyde dehydrogenase 8 family, member A1
UniProt Protein Function:
ALDH8A1: Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro). Belongs to the aldehyde dehydrogenase family. 4 isoforms of the human protein are produced by alternative splicing.
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010]
