The ALMS1 Polyclonal Antibody (PAC062563) is a valuable tool for researchers studying ALMS1, a protein associated with Alström Syndrome, a rare genetic disorder characterized by various symptoms including obesity, vision and hearing problems, and heart disease. This antibody, raised in rabbits, exhibits high specificity for human ALMS1 and has been validated for use in Western blot applications.ALMS1 is known to play a crucial role in ciliary function and intracellular trafficking processes, making it a key target for investigation in the fields of cell biology and genetics.
Research on ALMS1 has the potential to provide insights into the molecular mechanisms underlying Alström Syndrome, as well as other ciliopathies and genetic disorders. The ALMS1 Polyclonal Antibody enables researchers to detect and study ALMS1 expression in different cell types, facilitating a better understanding of its functions and roles in disease pathways.
Antibody Name:
ALMS1 Antibody (PACO62563)
Antibody SKU:
PACO62563
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Alstrom syndrome protein 1 protein (889-1057AA)
Immunofluorescence staining of Hela cells with PACO62563 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells.
Synonyms:
Alstrom syndrome protein 1, ALMS1, KIAA0328
UniProt Protein Function:
Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells.
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein containing a large tandem-repeat domain as well as additional low complexity regions. The encoded protein functions in microtubule organization, particularly in the formation and maintanance of cilia. Mutations in this gene cause Alstrom syndrome. There is a pseudogene for this gene located adjacent in the same region of chromosome 2. Alternative splice variants have been described but their full length nature has not been determined. [provided by RefSeq, Apr 2014]
