The Alpha-Amanitin Proprotein Antibody (PACO34041) is a high-quality polyclonal antibody designed for researchers studying the alpha-amanitin proprotein, a key component involved in RNA polymerase II inhibition. This antibody, produced in rabbits, has been extensively validated for use in various applications, including Western blotting and immunofluorescence.The alpha-amanitin proprotein is known for its potent inhibition of RNA polymerase II, making it a valuable tool in studying transcriptional regulation and gene expression. By targeting this proprotein with the PACO34041 antibody, researchers can effectively detect and analyze its presence in cells and tissues, providing valuable insights into its functional role in processes such as transcription and RNA synthesis.
With its high specificity and sensitivity, the Alpha-Amanitin Proprotein Antibody (PACO34041) is an essential tool for researchers in fields such as molecular biology, biochemistry, and toxicology. By utilizing this antibody, scientists can further elucidate the mechanisms underlying RNA polymerase II inhibition by alpha-amanitin, leading to a better understanding of its impact on cellular function and potential therapeutic applications in conditions related to transcriptional dysregulation.
Antibody Name:
Alpha-amanitin proprotein Antibody (PACO34041)
Antibody SKU:
PACO34041
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Amanita phalloides
Immunogen:
Peptide sequence from Amanita phalloides Alpha-amanitin proprotein protein
Major toxin from Amanita phalloideae. Acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters.
Function: Major toxin from Amanita phalloideae. Acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters. Ref.1 Ref.2 Ref.3 Ref.4Toxic dose: LD50 is 0.35 mg/kg by intraperitoneal injection into mice. LD50 is 4 mg/kg by intravenous injection into rats, and 0.1 mg/kg by intravenous injection into dogs. LD50 is 2 µg/kg by intracerebroventricular injection into mice, and 10 µg/kg by intracerebroventricular injection into rats. Ref.3Caution: This peptide is cyclic. The peptide order is assigned by homology with the gene sequence for alpha-amanitin from Amanita bisporigera. Ref.4In peptide sequencing work prior to 1968, the residue shown in the first position was reported as a beta-methylleucine derivative that could arise by either beta-methylation of leucine or gamma-methylation of isoleucine. The correct structure has been determined to be derived from isoleucine without methylation. Ref.4
