The ALS2CR11 Polyclonal Antibody (PAC015414) is a valuable tool for researchers studying ALS2CR11, a gene associated with Amyotrophic Lateral Sclerosis (ALS) and other neurodegenerative diseases. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ALS2CR11 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in neurobiology and neurodegenerative disease research.
ALS2CR11, also known as ALS2 C-terminal like protein, is implicated in the pathogenesis of ALS and other neurodegenerative disorders. Understanding the function and regulation of ALS2CR11 is crucial for unraveling the mechanisms underlying these devastating diseases and developing targeted therapies. The ALS2CR11 Polyclonal Antibody offers researchers a powerful tool for exploring the role of ALS2CR11 in disease pathology and potential therapeutic interventions.
Antibody Name:
ALS2CR11 Antibody (PACO15414)
Antibody SKU:
PACO15414
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human ALS2CR11
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, SKOV3 cells, mouse liver tissue, Primary antibody: PACO15414(ALS2CR11 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
Background:
This gene has highly expression in digestive system component and liver, biliary system. It may have four isoforms that produced by alternative splicing. Transcription profiling of human mesenchymal stem cells transformed with lentiviral vectors of TERT, E6, SV40 and RAS.
ALS2CR11: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 2q33.1Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
An autosomal recessive form of juvenile amyotrophic lateral sclerosis was originally mapped to a region of chromosome 2 that includes this gene. The encoded protein contains a calcium-dependent membrane targeting C2 domain. This domain is often found in proteins that are involved in membrane trafficking and signal transduction. [provided by RefSeq, Jun 2016]
