The AMDHD2 Polyclonal Antibody (PAC015419) is a valuable tool for researchers studying AMDHD2, a key enzyme involved in amino acid metabolism. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding to the AMDHD2 protein, this antibody facilitates detection and analysis in various cell types, making it a versatile option for studies in metabolic disorders, cancer research, and other related fields.
AMDHD2 is essential for the breakdown of amino acids and plays a crucial role in maintaining metabolic balance within cells. Dysregulation of AMDHD2 has been linked to disorders such as hyperammonemia and urea cycle disorders, making it a promising target for therapeutic interventions. Understanding the function and regulation of AMDHD2 is vital for developing strategies to treat these conditions and improve metabolic health.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15419(AMDHD2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: mouse heart tissue, Mouse liver tissue, Primary antibody: PACO15419(AMDHD2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15419(AMDHD2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid, (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
Synonyms:
amidohydrolase domain containing 2
UniProt Protein Function:
AMDHD2: Belongs to the NagA family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 3.5.1.25Chromosomal Location of Human Ortholog: 16p13.3Cellular Component: cytosol; nucleusMolecular Function: N-acetylglucosamine-6-phosphate deacetylase activity; protein bindingBiological Process: N-acetylglucosamine catabolic process; N-acetylneuraminate catabolic process; UDP-N-acetylglucosamine biosynthetic process
