The AMPK-1 Polyclonal Antibody (CAB21563) is specifically designed for research involving AMP-activated protein kinase (AMPK), a key enzyme involved in cellular energy homeostasis and metabolism regulation. The antibody, generated in rabbits, exhibits high reactivity with human samples and is verified for use in Western blot applications. By binding to the AMPK-1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable tool for studies in metabolic disorders, diabetes, cancer, and other related research areas.AMPK is a central regulator of cellular energy status, playing a crucial role in maintaining energy balance and responding to metabolic stress.
Dysregulation of AMPK activity has been implicated in various diseases, highlighting its potential as a therapeutic target. By studying the function and activity of AMPK-1, researchers can gain insights into metabolic pathways, signaling cascades, and potential treatment strategies for metabolic disorders and related conditions.In summary, the AMPK-1 Polyclonal Antibody (CAB21563) offers researchers a reliable tool for investigating the role of AMPK in cellular metabolism and energy regulation, with the potential to advance our understanding of metabolic diseases and inform the development of novel therapeutic interventions.
Product Name:
AMPKα1 Polyclonal Antibody
SKU:
CAB21563
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 421-520 of human AMPKα1. (NP_006242.5).
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Purification Method:
Affinity purification
Gene ID:
5562
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunofluorescence analysis of HeLa cells using AMPKα1 Rabbit pAb (CAB21563) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
