The AMZ1 Polyclonal Antibody (PACO19144) is a key tool for researchers studying the important cell surface molecule AMZ1. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the AMZ1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential resource for studies in immunology and cancer research.AMZ1 is known for its role in immune regulation, where it functions to inhibit immune responses. This molecule is crucial for maintaining immune balance and has implications in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
By better understanding the function of AMZ1, researchers can develop innovative therapies that target immune function and potentially improve treatment outcomes in these disease contexts.Overall, the AMZ1 Polyclonal Antibody (PACO19144) is a valuable tool for researchers looking to delve deeper into the role of AMZ1 in immune regulation and its impact on various disease states.
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, Human liver tissue, Primary antibody: PACO19144(AMZ1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19144(AMZ1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
AMZ1 shares sequence similarity with archaeal metalloproteases called archaemetzincins, but it appears to act predominantly as a basic aminopeptidase. Inhibited by the general metalloprotease inhibitors o-phenanthroline and batimastat. Also significantly inhibited by amastatin, which is an inhibitor of aminopeptidases. Not inhibited by 4-(2-aminoethyl)-benzenesulfonyl fluoride, E-64, and TIMPS (tissue inhibitors of metalloproteinases), which are inhibitors of serine, cysteine, and matrix metalloproteases, respectively.
Synonyms:
archaelysin family metallopeptidase 1
UniProt Protein Function:
AMZ1: Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family.Protein type: Protease; EC 3.-.-.-Chromosomal Location of Human Ortholog: 7p22.3
