The Ankrin Repeat Family A Protein 2 (ANKRA2) Polyclonal Antibody (PAC018562) is a valuable tool for researchers studying ANKRA2, a protein that belongs to the ankyrin repeat family known to be involved in various cellular processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to ANKRA2, this antibody enables the detection and analysis of the protein in different cell types, making it a versatile tool for research in the fields of molecular biology and cell signaling.
ANKRA2 is a protein with potential implications in cell adhesion, signal transduction, and protein-protein interactions. Its involvement in these processes suggests its relevance in physiological and pathological conditions, making it a promising target for further investigation. Understanding the role of ANKRA2 could provide insights into its function and potential therapeutic applications in diseases related to cellular dysfunction and signaling pathways.
Antibody Name:
ANKRA2 Antibody (PACO18562)
Antibody SKU:
PACO18562
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human ANKRA2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18562(ANKRA2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18562(ANKRA2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This protein may facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery. ANKRA2 is a megalin- and BKCa potassium channel-interacting factor. It is a protein known to interact with HDAC4 and HDAC5.ANKRA2 is important for transcriptional repression by AhRR.
Synonyms:
ankyrin repeat, family A (RFXANK-like), 2
UniProt Protein Function:
May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin ().
