The ANP32C Antibody (PAC018653) is a polyclonal antibody designed for research involving ANP32C, a protein known for its role in cellular processes such as apoptosis, transcription regulation, and RNA metabolism. The antibody, produced using rabbit immunization, is highly specific to human samples and is validated for use in Western blot applications. It binds to the ANP32C protein, allowing for accurate detection and analysis in a variety of cell types, making it an ideal tool for studies in molecular biology and cancer research.ANP32C, a member of the acidic nuclear phosphoprotein 32 family, is involved in multiple cellular functions and has been implicated in various disease processes, including cancer progression and neurodegenerative disorders.
Understanding the mechanisms of ANP32C activity is essential for unraveling its potential as a therapeutic target for conditions such as cancer and neurological diseases. Research using the ANP32C Antibody can provide valuable insights into the role of ANP32C in disease pathology and contribute to the development of novel treatment strategies.
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18653(ANP32C Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: PACO18653(ANP32C Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18653(ANP32C Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid, sequence to PP32 and are part of the same acid, c nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid, region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns.
Synonyms:
acid, c (leucine-rich) nuclear phosphoprotein 32 family, member C
UniProt Protein Function:
ANP32C: Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 4q32.3
UniProt Protein Details:
NCBI Summary:
Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]
