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GenieFluor 647 Anti-Mouse CD54 Antibody [YN1/1.7.4] (AGEL0122)

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SKU AGEL0122
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Rat
Isotype IgG2b
Clone YN1/1.7.4
Conjugation AF 647
Applications FC
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Description

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GenieFluor 647 Anti-Mouse CD54 Antibody [YN1/1.7.4]

The ANRTI Mouse CD54 Monoclonal Antibody (AGEL0122) is a powerful tool for research involving CD54, a cell adhesion molecule crucial for immune responses and inflammation regulation. This monoclonal antibody, conjugated with Alexa Fluor 647, is specifically designed for various applications including flow cytometry, immunofluorescence, and immunohistochemistry.CD54, also known as intercellular adhesion molecule-1 (ICAM-1), plays a pivotal role in mediating cell-cell interactions in the immune system. Its upregulation is often associated with inflammatory conditions and immune activation.

The ANRTI Mouse CD54 Monoclonal Antibody targets this key molecule, allowing for precise detection and visualization of CD54 expression in different cell types and tissues.With its high specificity and sensitivity, this antibody is a valuable tool for researchers in immunology, inflammation, and infectious diseases. By understanding the regulation and function of CD54, insights into immune responses, autoimmune disorders, and inflammatory processes can be gained, ultimately paving the way for innovative therapeutic approaches targeting CD54-mediated pathways.

Product Title:GenieFluor 647 Anti-Mouse CD54 Antibody [YN1/1.7.4]
SKU:AGEL0122
Size:50 Tests, 100 Tests, 200 Tests
Clone No:YN1/1.7.4
Synonyms:Intercellular adhesion molecule 1;Icam1;MALA-2;MyD10;CD54;Icam-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Genie Fluor 647 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P13597
Gene ID:15894
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

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