Description
Caspr2/CNTNAP2 Monoclonal Antibody (CAB19262)
The Caspr2/CNTNAP2 Monoclonal Antibody (CAB19262) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, demonstrates high specificity for human samples and has been validated for use in various applications including immunohistochemistry and Western blot.Caspr2, also known as Contactin-associated protein-like 2, is essential for the proper functioning of neurons and is implicated in neural development and function.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.
| Product Name: | Caspr2/CNTNAP2 Monoclonal Antibody |
| SKU: | CAB19262 |
| Size: | 20μL, 100μL |
| Reactivity: | Mouse, Rat |
| Clone Number: | ARC2430 |
| Conjugate: | Unconjugated |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. | ||||
| Sequence: | HLDH LDSA SADF PYNP GQGQ AIRN GVNR NSAI IGGV IAVV IFTI LCTL VFLI RYMF RHKG TYHT NEAK GAES AESA DAAI MNND PNFT ETID ESKK EWLI | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | CDFE, NRXN4, AUTS15, CASPR2, PTHSL1, Caspr2/CNTNAP2 |
| Positive Sample: | Mouse spinal cord, Rat brain |
| Cellular Localization: | Cell Projection, Membrane, Single-Pass Type I Membrane Protein, Axon. |
| Calculated MW: | 148kDa |
| Observed MW: | 152kDa |
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2, a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and intellectual disability.
| Purification Method | Affinity purification |
| Gene ID | 26047 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of various lysates using Caspr2/CNTNAP2 Rabbit mAb (CAB19262) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s. |
