The Anti-CD117 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0284) is a cutting-edge tool for researchers studying CD117, a cell surface receptor involved in a variety of cellular processes, including hematopoiesis and stem cell differentiation. This antibody, developed using rabbit monoclonal technology, exhibits high specificity and sensitivity towards CD117 in human samples, making it an ideal choice for Western blot and immunohistochemistry applications.CD117, also known as c-kit, plays a crucial role in various biological functions, such as cell proliferation, survival, and differentiation. Dysregulation of CD117 signaling has been linked to numerous diseases, including cancer and hematological disorders, making it a promising target for therapeutic intervention.
By utilizing this antibody, researchers can accurately detect and quantify CD117 expression in different cell types, advancing our understanding of its role in disease progression and treatment development.Overall, the Anti-CD117 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0284) is a valuable tool for investigating the mechanisms underlying CD117-mediated pathways and identifying potential therapeutic targets for various diseases. Its high specificity and reliability make it a crucial asset for researchers in the fields of oncology, hematopoiesis, and stem cell biology.
SKU:
HDAB0284
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC446
Synonyms:
C-Kit, CD117, MASTC, PBT, SCFR, KIT
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
