The Anti-CD3E/CD3G Antibody (CAB20213) is a valuable tool for researchers studying the CD3 complex, a critical component of T cell activation and function. This polyclonal antibody, generated in rabbits, specifically targets CD3E and CD3G proteins and is optimized for Western blot applications in human samples. The CD3 complex is essential for T cell receptor signaling and activation, making this antibody an essential tool for studies in immunology, oncology, and infectious diseases. By targeting these key components of T cell activation, researchers can gain valuable insights into immune responses and potential therapeutic targets for conditions such as cancer, autoimmune diseases, and infections.
With its high reactivity and specificity, the Anti-CD3E/CD3G Antibody is an invaluable resource for researchers looking to investigate the role of the CD3 complex in immune regulation and disease pathogenesis. Unlock the potential of T cell biology with this reliable and versatile antibody.
Product Name:
CD3E+CD3G Rabbit Monoclonal Antibody
SKU:
CAB20213
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-207(CD3E)& 1-182(CD3G) of human CD3 epsilon&CD3 gamma Heterodimer.
Cell membrane, Single-pass type I membrane protein, Membrane, Single-pass type I membrane protein.
Calculated MW:
23kDa
Observed MW:
23kDa
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency.
Purification Method:
Affinity purification
Gene ID:
916/917
Clone Number:
ARC5083-01
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CD3E+CD3G Rabbit mAb (CAB20213) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
