The Anti-CD56 Recombinant Rabbit Monoclonal Antibody (HDAB0193) is a powerful tool for research involving the CD56 protein, a cell surface marker found on natural killer cells and neural tissues. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in various applications, including immunohistochemistry and flow cytometry.CD56, also known as neural cell adhesion molecule (NCAM) or cluster of differentiation 56, plays a crucial role in cell adhesion, migration, and signaling in both the nervous and immune systems. Its expression on natural killer cells makes it a valuable marker for studying immune responses, while its presence in neural tissues suggests potential involvement in neurological disorders.
The Anti-CD56 Recombinant Rabbit Monoclonal Antibody allows for the specific detection and analysis of CD56 protein in various cell types, enabling researchers to explore its function in immunology, neuroscience, and cancer biology. By understanding the role of CD56 in different contexts, researchers can gain insights into disease mechanisms and potentially develop targeted therapies for conditions related to immune dysfunction or neural pathology.
SKU:
HDAB0193
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM202
Synonyms:
NCAM1, CD56, MSK39, NCAM
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.
