The Anti-CFB Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0249) is a powerful tool for researchers studying the complement factor B (CFB) protein and its role in the complement system. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.CFB is an essential component of the alternative pathway of the complement system, which plays a crucial role in innate immunity and inflammation. Dysregulation of the complement system has been implicated in various diseases, including autoimmune disorders, infectious diseases, and inflammatory conditions.
By targeting CFB, researchers can gain insight into the mechanisms underlying these diseases and potentially identify novel therapeutic targets.The Anti-CFB Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0249) specifically binds to CFB, allowing for precise detection and analysis of CFB expression in a range of cell types and tissues. This antibody is a valuable tool for investigating the function of CFB in immune response modulation and disease pathogenesis, making it ideal for studies in immunology, inflammation, and beyond.
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
