The Anti-FLT3LG chimeric recombinant rabbit monoclonal antibody (HDAB0265) is a cutting-edge tool for research involving FLT3LG, a cytokine involved in the regulation of hematopoietic cell proliferation and differentiation. This antibody, developed through advanced technologies, offers high specificity and sensitivity towards human samples, making it ideal for use in various research applications, including Western blotting.FLT3LG, also known as FMS-like tyrosine kinase 3 ligand, is a crucial factor in the development of immune cells and has been implicated in various hematologic malignancies and immune disorders. The Anti-FLT3LG antibody binds specifically to the FLT3LG protein, enabling researchers to detect and analyze its expression in different cell types.
This makes it a valuable tool for investigations in immunology, oncology, and other related fields.By using the Anti-FLT3LG antibody, researchers can gain insights into the role of FLT3LG in immune regulation and hematopoiesis, potentially leading to the development of novel therapeutic strategies for diseases associated with dysregulated immune responses. Its high specificity and sensitivity make it a reliable tool for studying the complex functions of FLT3LG in health and disease.
SKU:
HDAB0265
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC421
Synonyms:
FLT3LG, FL, FLT3L, Flt3 ligand
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.
