The GM-CSF Recombinant Rabbit Monoclonal Antibody (HDAB0191) is a valuable tool for researchers studying GM-CSF, a cytokine involved in immune regulation and inflammation. This antibody, produced in rabbits, demonstrates high specificity and sensitivity in detecting GM-CSF in human samples, making it ideal for applications such as Western blotting.GM-CSF plays a crucial role in the regulation of the immune system, particularly in the differentiation and activation of various immune cells. Dysregulation of GM-CSF signaling has been implicated in inflammatory disorders, autoimmune diseases, and cancer.
Studying the expression and activity of GM-CSF using this antibody can provide insights into the mechanisms underlying these conditions and potentially identify therapeutic targets.With its high reactivity and reliability, the GM-CSF Recombinant Rabbit Monoclonal Antibody (HDAB0191) is a valuable tool for researchers seeking to advance our understanding of immune regulation and inflammation in health and disease.
SKU:
HDAB0191
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM200
Synonyms:
CSF, GMCSF
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis. [provided by RefSeq, Aug 2020]
