The Anti-GPC3 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0254) is a powerful tool for research involving GPC3, a glypican protein implicated in various biological processes and diseases, including cancer. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting GPC3 in human samples, making it a valuable asset for studies in oncology and cell biology.GPC3, a cell surface protein, is known to play a critical role in cell growth, differentiation, and migration, making it a promising therapeutic target in cancer treatment. The Anti-GPC3 Antibody binds specifically to GPC3, allowing for accurate detection and analysis in a wide range of cell types, paving the way for in-depth research into the mechanisms underlying GPC3-related diseases.
With its superior performance and reliability in various applications, including Western blotting, immunohistochemistry, and flow cytometry, the Anti-GPC3 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0254) is an essential tool for researchers looking to unravel the complexities of GPC3 biology and its implications in cancer progression and therapy.
SKU:
HDAB0254
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC371
Synonyms:
DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] References： Fu Ying,Urban Daniel J,Nani Roger R et al. Glypican-3-Specific Antibody Drug Conjugates Targeting Hepatocellular Carcinoma.[J] .Hepatology, 2019, 70: 563-576. Zhang Yi-Fan,Ho Mitchell,Humanization of high-affinity antibodies targeting glypican-3 in hepatocellular carcinoma.
