The Anti-IL18RA Recombinant Rabbit Monoclonal Antibody (HDAB0208) is a highly specific and sensitive tool for research involving IL18RA, a cell surface receptor involved in regulating immune responses. This antibody, generated in rabbits, is optimized for use in various applications such as Western blotting and immunohistochemistry, providing reliable detection and analysis of IL18RA in human samples.IL18RA, also known as interleukin-18 receptor alpha, is a key player in the interleukin-18 signaling pathway, which is known to modulate inflammatory responses and immune cell activation.
Dysregulation of this pathway has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and cancer. By utilizing the Anti-IL18RA Recombinant Rabbit Monoclonal Antibody, researchers can gain valuable insights into the role of IL18RA in these disease contexts, ultimately advancing our understanding and potential therapeutic strategies targeting this important immune receptor.
SKU:
HDAB0208
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM218
Synonyms:
CD218a, CDw218a, IL-1Rrp, IL1RRP, IL18RA
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
