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Anti-Phospho-GSK3 (alpha + beta) (Tyr279/Tyr216) [R01-5G6] Monoclonal Antibody (AGMB05096)

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SKU:
AGMB05096
Antibody Type:
Monoclonal Antibody
Size:
20μL, 50μL, 100μL
Reactivity:
Human, Mouse, Rat
Host Species:
Rabbit
$165 - $634
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Description

Product Name: Anti-Phospho-GSK3 (alpha + beta) (Tyr279/Tyr216) [R01-5G6] Monoclonal Antibody
SKU: AGMB05096
Size: 20μL, 50μL, 100μL
Host Species: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
Clone Number: R01-5G6
Conjugate: Unconjugated
Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Tyr216 of human GSK3 alpha.
Tested Applications: WB IHC-P ICC/IF IP
Recommended Dilution:
WB 1:500 – 1:1000
IHC-P 1:20 – 1:50
IP 1:20 – 1:50
Synonyms: GSK3α/β, Serine/threonine-protein kinase GSK3A, Serine/threonine-protein kinase GSK3B
Modification: Phosphorylated
Calculated MW: 51kDa
Observed MW: 47–51kDa

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

Purification Method: Affinity Purified
Gene ID: 2931 / 2932
Buffer: 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% glycerol, 0.01% sodium azide and 0.05% BSA.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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