The Phospho-STING/TMEM173-S366 Polyclonal Antibody (CABP1223) is a high-quality antibody developed for reliable detection and analysis of target proteins. This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. RRID Gene ID 340061 Swiss Prot Synonym ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta; Phospho-STING/TMEM173-S366
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
Phospho-STING/TMEM173-S366 Polyclonal Antibody
SKU:
CABP1223
Size:
100μL, 20μL
Reactivity:
Human
Clone Number:
-
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Tested Applications:
WBELISA
Recommended Dilution:
WB
1:500 - 1:1000
ELISA
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Autophagosome, Cytosol, Endosome, Mitochondrial Outer Membrane, Nucleoplasm, Perinuclear Region Of Cytoplasm, Peroxisome, Plasma Membrane.
Calculated MW:
42kDa
Observed MW:
40kDa
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. RRID Gene ID 340061 Swiss Prot Synonym ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta; Phospho-STING/TMEM173-S366
Purification Method:
Affinity purification
Gene ID:
340061
RRID:
-
Buffer Information:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from THP-1 cells using Phospho-STING/TMEM173-S366 Rabbit pAb (CABP1223) at 1:500 dilution. THP-1 cells were differentiation with TPA (200 nM) for 15 minutes and transfection with poly(dA:dT) (5ug/mL) for 3 hours. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 30s.
