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Anti-SARS-CoV-2 Spike NTD [2146] - Biotin (IVMB0226)

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SKU:
IVMB0226
Product Type:
Recombinant Monoclonal Antibody
Clone:
2146
Protein:
SARS-CoV-2 Spike NTD
Synonyms:
COV2-2146, SARS-CoV2 Spike NTD, COVID-19, 2019-nCoV, Severe acute respiratory syndrome coronavirus 2, SARS-CoV2
Isotype:
Human IgG1
Reactivity:
Virus
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Description

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Product Name:Anti-SARS-CoV-2 Spike NTD [2146] - Biotin
Product Code:IVMB0226
Clone:2146
Protein:SARS-CoV-2 Spike NTD
Product Type:Recombinant Monoclonal Antibody
Synonyms:COV2-2146, SARS-CoV2 Spike NTD, COVID-19, 2019-nCoV, Severe acute respiratory syndrome coronavirus 2, SARS-CoV2
Isotype:Human IgG1
Reactivity:SARS-CoV-2 ? Virus
Immunogen:Sequenced from human survivors of COVID-19 (SARS-CoV-2)
Applications:ELISA, IHC
Storage and Handling:This biotinylated monoclonal antibody is stable when stored at 2-8°C. Do not freeze.
Applications:ELISA, IHC
Recommended Usage:ELISA
Reactivity:SARS-CoV-2 ? Virus
Specificity:Anti-SARS-CoV-2 Spike NTD-Biotin, clone 2146, specifically targets an epitope on the SARS-CoV-2 spike protein N-terminal domain.
Antigen Distribution:The spike NTD is expressed on the surface of the SARS-CoV-2 virus.
Immunogen:Sequenced from human survivors of COVID-19 (SARS-CoV-2)
Concentration:0.5 mg/ml
Storage and Handling:This biotinylated monoclonal antibody is stable when stored at 2-8°C. Do not freeze.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is an enveloped, single-stranded, positive-sense RNA virus that belongs to the Coronaviridae family 1. The SARS-CoV-2 genome, which shares 79.6% identity with SARS-CoV, encodes four essential structural proteins: the spike (S), envelope (E), membrane (M), and nucleocapsid protein (N) 2. The S protein is a transmembrane, homotrimeric, class I fusion glycoprotein that mediates viral attachment, fusion, and entry into host cells 3. Each ~180 kDa monomer contains two functional subunits, S1 (~700 a.a) and S2 (~600 a.a), that mediate viral attachment and membrane fusion, respectively. S1 contains two major domains, the N-terminal (NTD) and C-terminal domains (CTD). In both SARS-CoV and SARS-CoV-2, the CTD contains the receptor-binding domain (RBD), which binds to the angiotensin-converting enzyme 2 (ACE2) receptor on host cells3-5. The NTD of SARS-CoV-2 does not bind to ACE26, and the function of NTD in SARS-CoV-2 infection is not well understood. In other CoVs, the NTD may promote attachment by binding to sugar moieties7 and might play a role in the conformational change of S2 required for membrane fusion8. While most neutralizing antibodies target the RBD domain and block receptor binding, potent neutralizing antibodies targeting NTD were isolated from convalescent COVID19 patients9, identifying the NTD as an attractive candidate for vaccines and therapeutics. In addition, the NTD is a promising antigen for diagnostic tests, as there is only 53.5% homology between the NTD of SARS-CoV-2 and SARS-CoV10.
Protein:SARS-CoV-2 Spike NTD
Research Area:COVID-19, Viral

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