The SRGAP2 Polyclonal Antibody (CAB19512) is a valuable tool for researchers studying SRGAP2, a protein involved in neuronal development and synaptic signaling. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the SRGAP2 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies in neuroscience and neurodevelopmental disorders.
SRGAP2, also known as Slit-Robo Rho GTPase activating protein 2, plays a crucial role in neuronal migration, dendritic spine formation, and synaptic plasticity. Dysregulation of SRGAP2 has been linked to cognitive impairments, autism spectrum disorders, and other neurological conditions. By understanding the function of SRGAP2, researchers can gain insights into the molecular mechanisms underlying brain development and neurological diseases, paving the way for potential therapeutic interventions.
Product Name:
SRGAP2 Rabbit Polyclonal Antibody
SKU:
CAB19512
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 790-900 of human SRGAP2 (NP_056141.2).
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.
Purification Method:
Affinity purification
Gene ID:
23380
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SRGAP2 Rabbit pAb (CAB19512) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
