The ZIP4 Polyclonal Antibody (CAB20588) is a valuable tool for researchers studying the zinc transporter ZIP4, a key protein involved in zinc homeostasis and cellular function. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to ZIP4, this antibody allows for the detection and analysis of ZIP4 expression in various cell types, making it particularly useful for studies in metabolism, immune function, and cancer research.
ZIP4 is essential for the uptake of zinc into cells and plays a crucial role in zinc signaling pathways, impacting processes such as immune response, cell growth, and DNA synthesis. Dysregulation of ZIP4 expression has been linked to various diseases, including cancer, where altered zinc metabolism can influence tumorigenesis and tumor progression. By studying the function of ZIP4, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Product Name:
ZIP4 Rabbit Polyclonal Antibody
SKU:
CAB20588
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Oryza sativa
Immunogen:
Recombinant protein of Oryza sativa ZIP4
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
ZIP4; OsZIP4; OsJ_04366; B1078G07.1
Positive Sample:
Spikes
Conjugate:
Unconjugated
Cellular Localization:
nucleus
Calculated MW:
103kDa
Observed MW:
103kDa
Required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference-sensitive crossovers (class I meiotic crossover) and works cooperatively with MER3 to promote crossovers.
Purification Method:
Affinity purification
Gene ID:
4324913
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various tissues from the japonica rice (Oryza sativa L.) variety Zhonghua 11, using ZIP4 Rabbit pAb (CAB20588) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
