The AP3M2 Polyclonal Antibody (PAC00771) is a valuable tool for researchers studying AP3M2, a key protein involved in intracellular protein trafficking and vesicle formation processes. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for Western blot applications. By binding specifically to the AP3M2 protein, researchers can accurately detect and analyze its expression in various cell types, making it a versatile tool for studies in cell biology and molecular biology.
AP3M2 plays a crucial role in the sorting and delivery of proteins within cells, making it important for understanding cellular processes such as protein transport, membrane dynamics, and organelle function. Dysregulation of AP3M2 function has been implicated in various diseases, including neurodegenerative disorders and metabolic syndromes. By characterizing the role of AP3M2 in these conditions, researchers can gain insights into potential therapeutic targets and strategies for treating these diseases.
adaptor-related protein complex 3, mu 2 subunit;AP3M2;AP47B;CLA20;P47B ;
UniProt Protein Function:
AP3M2: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Belongs to the adaptor complexes medium subunit family.Chromosomal Location of Human Ortholog: 8p11.2Cellular Component: Golgi apparatus; cytoplasmic vesicle membrane; clathrin adaptor complex; AP-type membrane coat adaptor complexBiological Process: intracellular protein transport; anterograde synaptic vesicle transport; anterograde axon cargo transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008]
