The APBB1 Polyclonal Antibody (CAB1944) is a valuable tool for researchers studying APBB1, a protein involved in various cellular processes, including Alzheimer's disease. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. APBB1, also known as amyloid beta precursor protein-binding family B member 1, plays a crucial role in the metabolism of amyloid precursor protein (APP), which is involved in the pathological processes of Alzheimer's disease.
By targeting APBB1 with this antibody, researchers can further investigate the mechanisms underlying APP metabolism and its implications in neurodegenerative disorders.The APBB1 Polyclonal Antibody is a valuable tool for researchers exploring the role of APBB1 in Alzheimer's disease and other related conditions. Its high specificity and sensitivity make it ideal for detecting and analyzing APBB1 in various experimental settings, providing valuable insights into the molecular pathways involved in neurodegeneration.
Product Name:
APBB1 Rabbit Polyclonal Antibody
SKU:
CAB1944
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 359-708 of human APBB1 (NP_663722.1).
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
322
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using APBB1 antibody (CAB1944) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
