The APBB2 Polyclonal Antibody (PACO04064) is a valuable tool for researchers studying the APBB2 protein, a key player in Alzheimer's disease pathology. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot analysis. By specifically binding to the APBB2 protein, this antibody enables precise detection and analysis in different cell types, making it essential for investigations in neurology and neurodegenerative disorders.APBB2, also referred to as amyloid beta precursor protein-binding family B member 2, is involved in the processing and metabolism of amyloid beta precursor protein, which is central to the formation of amyloid plaques in Alzheimer's disease.
Research on APBB2 can provide insights into the molecular mechanisms underlying Alzheimer's pathology and may guide the development of potential therapies targeting this protein. Understanding the role of APBB2 is critical for advancing our knowledge of Alzheimer's disease and exploring novel treatment strategies.
Antibody Name:
APBB2 Antibody
Antibody SKU:
PACO04064
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human Fe65L.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
APBB2; FE65L; FE65L1; Amyloid beta A4 precursor protein-binding family B member 2; Protein Fe65-like 1
UniProt Protein Function:
APBB2: May modulate the internalization of beta-amyloid precursor protein. 3 isoforms of the human protein are produced by alternative splicing.Protein type: ApoptosisChromosomal Location of Human Ortholog: 4p13Cellular Component: cytoplasm; growth cone; lamellipodium; membrane; nucleus; synapseMolecular Function: beta-amyloid binding; protein binding; transcription factor bindingBiological Process: axon guidance; cell cycle arrest; extracellular matrix organization and biogenesis; negative regulation of apoptosis; negative regulation of cell growth; neuron migration; positive regulation of apoptosis; regulation of transcription, DNA-dependentDisease: Alzheimer Disease
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
