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Key Features

APC Anti-Mouse CD107a Antibody [1D4B] (AGEL3288)

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SKU AGEL3288
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Applications ICFCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2a, k
Clone 1D4B
Conjugation APC
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Description

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APC Anti-Mouse CD107a Antibody [1D4B]

The APC Anti-Mouse CD107a Antibody (1D4B) is a powerful tool for research involving CD107a, a cell surface marker widely used as a marker for degranulation and cytotoxic activity in various immune cell types, particularly natural killer cells and cytotoxic T cells. This antibody, specifically designed for use in mouse samples, is a monoclonal antibody that has been rigorously validated for flow cytometry applications.CD107a, also known as LAMP-1, is a crucial protein involved in the secretion of lytic granules containing cytolytic molecules, playing a key role in immune surveillance and defense mechanisms against infected or cancerous cells. By targeting and binding to CD107a, researchers can accurately detect and quantify the degranulation process, essential for studying immune cell function and assessing immune responses in different experimental settings.

The APC Anti-Mouse CD107a Antibody (1D4B) offers exceptional specificity and sensitivity in flow cytometry assays, enabling precise analysis of degranulation events and cytotoxic activity in immune cells. Its reliable performance and reproducibility make it an invaluable tool for investigating immune responses, studying antitumor immunity, and evaluating the efficacy of immunotherapies in preclinical research. Unlock the potential of your immune cell studies with the APC Anti-Mouse CD107a Antibody (1D4B) from AssayGenie.

Product Title:APC Anti-Mouse CD107a Antibody [1D4B]
SKU:AGEL3288
Size:50 Tests, 100 Tests, 200 Tests
Clone No:1D4B
Synonyms:LAMP-1;Lysosome-associated membrane glycoprotein 1; lysosomal membrane glycoprotein 1; CD107 antigen-like family member A; lysosome-associated membrane protein 1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P11438
Gene ID:16783
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The 1D4B antibody recognizes CD107a which is also known as, Lysosome-Associated Membrane Protein 1 (LAMP-1). CD107a is one of the two major glycoproteins in lysosome membranes that provide useful markers to distinguish lysosomes from other organelles. CD107a may play a role in the lysosomal degradation of certain molecules. Mouse CD107a is a type I transmembrane glycoprotein. It consists of a 40-kDa core protein which is heavily glycosylated to form heterogeneous mature glycoprotein of 110-140 kDa. It is principally expressed in epithelial cells and macrophages in a variety of organs. Following activation, CD107a is relocated to the surface of some lymphocytes, macrophages, epithelial cells, endothelial cells, platelets, and tumor cells. Cell-surface CD107a may participate in intercellular adhesion and adhesion to the extracellular matrix. Cell surface CD107a expression can serve as a useful marker for cytotoxic NK and CD8+ T cells, as well as, some malignant tumor cells.

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