The APLN Polyclonal Antibody (PAC020970) is a valuable tool for researchers studying APLN, a peptide hormone involved in various physiological processes, including cardiovascular regulation and angiogenesis. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting APLN in human samples, making it ideal for use in applications such as Western blotting.APLN, also known as apelin, has been implicated in numerous disease processes, including cardiovascular disorders, obesity, and cancer.
By targeting APLN with this antibody, researchers can further elucidate its role in these conditions and potentially uncover new therapeutic targets. The ability to accurately detect APLN in different cell types makes this antibody a versatile tool for investigations in the fields of cardiovascular biology and cancer research.
Antibody Name:
APLN Antibody (PACO20970)
Antibody SKU:
PACO20970
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human APLN
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20970(APLN Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
Synonyms:
apelin
UniProt Protein Function:
apelin: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. Belongs to the apelin family.
UniProt Protein Details:
Protein type:Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: extracellular space; extracellular region
Biological Process: lactation; immune response; signal transduction
NCBI Summary:
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]
