The APOOL Polyclonal Antibody (PACO25014) is a high-quality antibody designed for research involving the A-kinase anchor protein-like (APOOL) protein. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blotting. By specifically binding to the APOOL protein, this antibody enables detection and analysis in a variety of cell types, making it an ideal tool for studies in cell biology and molecular biology research.APOOL is a protein that plays a crucial role in the regulation of mitochondrial membrane morphology and function.
By studying the activity of the APOOL protein, researchers can gain valuable insights into the mechanisms underlying mitochondrial dynamics and function, as well as their implications in various diseases, such as neurodegenerative disorders and metabolic diseases. The APOOL Polyclonal Antibody is a valuable tool for researchers looking to explore the functions and pathways involving the APOOL protein and its potential role in disease development and progression.
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO25014 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human heart tissue using PACO25014 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human colon tissue using PACO25014 at dilution of 1:100.
Background:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979).
APOOL: a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]Protein type: Secreted, signal peptide; Secreted; MitochondrialChromosomal Location of Human Ortholog: Xq21.1Cellular Component: mitochondrionMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]
