The ARHGAP15 Polyclonal Antibody (PACO07819) is a key tool for researchers studying ARHGAP15, a protein involved in cell signaling and cytoskeletal organization. This antibody is produced in rabbits and is highly specific to human samples, allowing for reliable results in various experimental applications, including Western blotting.ARHGAP15, also known as Rho GTPase activating protein 15, plays a crucial role in regulating Rho GTPase activity, which is involved in processes such as cell migration, adhesion, and morphogenesis. Dysregulation of ARHGAP15 has been implicated in diseases like cancer and neurological disorders, making it an important target for further investigation.
By utilizing the ARHGAP15 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of ARHGAP15 in different cell types and disease states. This antibody enables precise detection and analysis of ARHGAP15 protein levels, facilitating in-depth studies in fields such as cell biology, cancer research, and neurobiology. Unlock the potential of ARHGAP15 research with this high-quality, validated antibody.
ARHGAP15: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 2q22.2-q22.3Cellular Component: membrane; cytosolBiological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]
