The ARHGAP15 Polyclonal Antibody (PAC01507) is a valuable tool for researchers studying ARHGAP15, a protein involved in cellular signaling pathways and actin cytoskeleton organization. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and has been validated for use in Western blot applications.ARHGAP15, also known as Rho GTPase-activating protein 15, plays a crucial role in regulating Rho GTPase activity, which in turn influences cell migration, adhesion, and shape. Its involvement in these processes makes it a key player in cancer progression, making it a promising target for cancer research and drug development.
By using the ARHGAP15 Polyclonal Antibody, researchers can accurately detect and analyze the presence of ARHGAP15 in various cell types, providing valuable insights into its function and potential as a therapeutic target. This antibody is particularly useful for studies in cell biology, cancer biology, and drug discovery, offering a robust tool for investigating the role of ARHGAP15 in disease development and progression.
Antibody Name:
ARHGAP15 Antibody (PACO15507)
Antibody SKU:
PACO15507
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human ARHGAP15
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15507(ARHGAP15 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15507(ARHGAP15 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]). GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.
Synonyms:
Rho GTPase activating protein 15
UniProt Protein Function:
ARHGAP15: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 2q22.2-q22.3Cellular Component: membrane; cytosolBiological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]
