The ARHGAP18 Polyclonal Antibody (PACO06261) is a valuable tool for researchers studying ARHGAP18, a protein involved in cellular processes such as cytoskeletal organization and cell migration. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ARHGAP18 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in cell biology and cancer research.ARHGAP18, also known as Rho GTPase-activating protein 18, plays a crucial role in regulating Rho GTPases, which are key molecules involved in controlling cell shape, movement, and division. Dysregulation of ARHGAP18 has been linked to various diseases, including cancer, cardiovascular disorders, and neurological conditions.
Investigating the function of ARHGAP18 can provide valuable insights into these pathologies and help identify potential targets for therapeutic intervention.The ARHGAP18 Polyclonal Antibody is a reliable tool for researchers interested in exploring the molecular mechanisms underlying ARHGAP18-mediated cellular processes and its potential implications in disease development. By using this antibody, researchers can further elucidate the role of ARHGAP18 in normal physiology and disease pathology, paving the way for future advancements in biomedical research and drug discovery.
Antibody Name:
ARHGAP18 Antibody (PACO06261)
Antibody SKU:
PACO06261
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the C-terminal region of human ARHGAP18.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of NIH-3T3 cells using ARHGAP18 Polyclonal Antibody.
Western Blot analysis of Jurkat cells using ARHGAP18 Polyclonal Antibody.
Synonyms:
ARHGAP18; Rho GTPase-activating protein 18; MacGAP; Rho-type GTPase-activating protein 18
UniProt Protein Function:
ARHGAP18: a GTPase activator for the Rho-type GTPases, converting them to inactive GDP-bound states. Two alternatively-spliced isoforms have been described.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 6q22.33Cellular Component: cytoplasm; cytosolMolecular Function: GTPase activator activityBiological Process: regulation of actin cytoskeleton organization and biogenesis; regulation of actin filament polymerization; regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]
