The ARHGAP9 Polyclonal Antibody (PACO07827) is a valuable tool for researchers studying ARHGAP9, a protein involved in cell signaling and cytoskeletal dynamics. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the ARHGAP9 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential resource for studies in molecular biology and cell biology.ARHGAP9, also known as Rho GTPase activating protein 9, plays a crucial role in regulating Rho GTPase signaling pathways that control important cellular processes such as cell migration, cell division, and cell adhesion.
Dysregulation of ARHGAP9 has been implicated in various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. By understanding the function of ARHGAP9, researchers can develop targeted therapies to manipulate Rho GTPase signaling and potentially treat diseases associated with its dysfunction.
Rho GTPase activating protein 9;ARHGAP9;10C;FLJ16525;MGC1295;RGL1 ;
UniProt Protein Function:
ARHGAP9: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. 4 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; Cell adhesion; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 12q13.3Cellular Component: cytosolMolecular Function: phosphatidylinositol-3,4,5-triphosphate binding; GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
