The ARHGDIG Polyclonal Antibody (PACO01430) is a powerful tool for researchers studying ARHGDIG, a protein involved in cell signaling and immune response regulation. This antibody, produced in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By binding to ARHGDIG, this antibody enables precise detection and analysis in various cell types, making it an excellent choice for studies in immunology, cancer research, and beyond.
ARHGDIG, also known as Rho GDP-dissociation inhibitor gamma, plays a crucial role in modulating immune responses and cell migration. Its involvement in these processes suggests its potential significance in diseases such as cancer, autoimmune disorders, and inflammatory conditions. By elucidating the functions of ARHGDIG, researchers can gain valuable insights into potential therapeutic targets for manipulating immune responses in various pathological conditions.
Antibody Name:
ARHGDIG Antibody
Antibody SKU:
PACO01430
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human Rho GDIgamma.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
RhoGDI gamma: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP. Belongs to the Rho GDI family.Protein type: Inhibitor; Motility/polarity/chemotaxis; G protein regulator, misc.; Cell adhesionChromosomal Location of Human Ortholog: 16p13.3Cellular Component: membrane; cytoplasmic membrane-bound vesicle; cytosolMolecular Function: Rho GDP-dissociation inhibitor activity; GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction; regulation of protein localization; small GTPase mediated signal transduction; negative regulation of cell adhesion; Rho protein signal transduction; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
