The ARHGEF10 Monoclonal Antibody (PACO00420) is a valuable tool for researchers studying ARHGEF10, a key protein involved in actin cytoskeleton organization and cell migration. This antibody, developed using hybridoma technology, is highly specific to human samples and has been validated for use in immunofluorescence and immunohistochemistry applications.ARHGEF10, also known as Rho guanine nucleotide exchange factor 10, plays a crucial role in regulating Rho GTPases, which are essential for various cellular processes, including cell shape and motility.
Dysregulation of ARHGEF10 has been implicated in cancer metastasis and neurological disorders, making it a promising target for therapeutic intervention.By utilizing the ARHGEF10 Monoclonal Antibody, researchers can conduct detailed studies into the function and localization of ARHGEF10 within cells, aiding in the understanding of its role in health and disease. This antibody is a valuable asset for investigations into cell biology, cancer biology, and neurobiology, providing insights that may ultimately lead to the development of novel treatments.
Antibody Name:
ARHGEF10 Antibody
Antibody SKU:
PACO00420
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Monkey
Immunogen:
synthesized peptide derived from the Internal region of human ARHGEF10.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs, Rac/Rho; GEFsChromosomal Location of Human Ortholog: 8p23Cellular Component: centrosome; cytosolMolecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; kinesin bindingBiological Process: positive regulation of stress fiber formation; centrosome duplication; myelination in the peripheral nervous systemDisease: Slowed Nerve Conduction Velocity, Autosomal Dominant
UniProt Protein Details:
NCBI Summary:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. [provided by RefSeq, Jul 2008]
