The ARHGEF16 Polyclonal Antibody (PAC007833) is a valuable tool for researchers studying ARHGEF16, a Rho guanine nucleotide exchange factor implicated in cell signaling pathways and cytoskeletal dynamics. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the ARHGEF16 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and cancer research.ARHGEF16 plays a crucial role in modulating the activity of Rho GTPases, which are key regulators of cell migration, adhesion, and proliferation.
Dysregulation of ARHGEF16 has been associated with various diseases, including cancer, cardiovascular disorders, and neurological conditions. Studying the function of ARHGEF16 can provide valuable insights into the mechanisms underlying these diseases and offer potential therapeutic targets for intervention.Overall, the ARHGEF16 Polyclonal Antibody is a reliable tool for researchers interested in investigating the role of ARHGEF16 in cellular processes and disease pathogenesis. Its high specificity and sensitivity make it a valuable asset for advancing our understanding of Rho GTPase signaling pathways and their implications in human health and disease.
ARHGEF16: a Rho guanine exchange factor protein that contains 1 DH, 1 PH and 1 SH3 domain.Protein type: GEFs; Motility/polarity/chemotaxis; GEFs, Rac/RhoChromosomal Location of Human Ortholog: 1p36.3Cellular Component: cytosolMolecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; Rho GTPase binding; receptor tyrosine kinase binding; PDZ domain bindingBiological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]
