The ARHGEF19 Polyclonal Antibody (PACO22574) is a valuable tool for researchers studying ARHGEF19, a protein known for its involvement in cellular signaling pathways and cytoskeleton regulation. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications.ARHGEF19, also known as leukemia-associated Rho guanine nucleotide exchange factor (LARG), plays a crucial role in cell migration, adhesion, and differentiation processes. Its dysregulation has been linked to various diseases, including cancer and neurological disorders.
By targeting ARHGEF19 with this polyclonal antibody, researchers can detect and analyze the protein in different cell types, aiding in the investigation of its function and potential therapeutic implications.The ARHGEF19 Polyclonal Antibody (PACO22574) is a valuable tool for advancing research in cell biology, cancer biology, and other related fields. Its specificity and sensitivity make it an ideal choice for studies aiming to unravel the complexities of ARHGEF19-mediated signaling pathways and their impact on disease development and progression.
Antibody Name:
ARHGEF19 Antibody (PACO22574)
Antibody SKU:
PACO22574
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human ARHGEF19.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using ARHGEF19 antibody.
Background:
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase By similarity.
ARHGEF19: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs, Rac/Rho; GEFsChromosomal Location of Human Ortholog: 1p36.13Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; GTPase activator activityBiological Process: wound healing; regulation of actin cytoskeleton organization and biogenesis
UniProt Protein Details:
NCBI Summary:
Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).[supplied by OMIM, Dec 2008]
