The ARL8A Antibody (PAC015526) is a high-quality polyclonal antibody specifically designed for research involving ARL8A, a small GTPase protein involved in regulating lysosome function and membrane trafficking. This antibody, produced in rabbits, is highly specific and recommended for use in a variety of research applications, including Western blotting, immunofluorescence, and immunoprecipitation.ARL8A plays a crucial role in cellular processes such as autophagy, endocytosis, and lysosomal positioning. Dysregulation of ARL8A has been implicated in diseases such as cancer, neurodegenerative disorders, and lysosomal storage disorders.
This antibody enables researchers to detect and study the expression and localization of ARL8A in different cell types, providing valuable insights into its function and potential therapeutic implications.With its high specificity and reliability, the ARL8A Antibody (PAC015526) is an essential tool for scientists conducting research in cell biology, molecular biology, and related fields. Its versatile applications make it suitable for studying a wide range of cellular processes and disease mechanisms, making it a valuable asset in the pursuit of understanding and treating various health conditions.
Antibody Name:
ARL8A Antibody (PACO15526)
Antibody SKU:
PACO15526
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human ARL8A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO15526(ARL8A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15526(ARL8A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
ARL8A (ADP-ribosylation factor-like protein 8A), also known as ARL10B or GIE2, is a 186 amino acid, protein that localizes to the membrane of late endosomes. Expressed ubiquitously, ARL8A is thought to play a role in lysosomal motility and may also be involved in chromosomal segregation events. The gene encoding ARL8A maps to human chromosome 1, which spans 260 million base pairs, houses over 3,000 genes and comprises nearly 8% of the human genome.
Synonyms:
ADP-ribosylation factor-like 8A
UniProt Protein Function:
ARL8A: May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation. Belongs to the small GTPase superfamily. Arf family.Protein type: G protein, monomeric; G protein, monomeric, ARFChromosomal Location of Human Ortholog: 1q32.1Cellular Component: cytoplasm; lysosomal membrane; membrane; midbody; spindle midzoneMolecular Function: alpha-tubulin binding; beta-tubulin binding; GTP binding; protein bindingBiological Process: chromosome segregation
