The ARL8A Polyclonal Antibody (PAC015527) is a valuable tool for researchers studying the cellular functions of ARL8A, a small GTPase protein involved in lysosomal trafficking and autophagy. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot experiments. By binding to the ARL8A protein, this antibody allows for precise detection and analysis of ARL8A in various cell types, making it an essential component for studies in cell biology and autophagy research.ARL8A is known to play a key role in the regulation of lysosomal positioning and function, as well as in the fusion of lysosomes with other organelles.
Its involvement in autophagy and cellular homeostasis makes it a promising target for investigation in diseases related to lysosomal dysfunction, such as neurodegenerative disorders and lysosomal storage diseases. By studying the function of ARL8A, researchers can gain insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets for intervention.
Antibody Name:
ARL8A Antibody (PACO15527)
Antibody SKU:
PACO15527
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human ARL8A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15527(ARL8A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15527(ARL8A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
ARL8A (ADP-ribosylation factor-like protein 8A), also known as ARL10B or GIE2, is a 186 amino acid, protein that localizes to the membrane of late endosomes. Expressed ubiquitously, ARL8A is thought to play a role in lysosomal motility and may also be involved in chromosomal segregation events. The gene encoding ARL8A maps to human chromosome 1, which spans 260 million base pairs, houses over 3,000 genes and comprises nearly 8% of the human genome.
Synonyms:
ADP-ribosylation factor-like 8A
UniProt Protein Function:
ARL8A: May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation. Belongs to the small GTPase superfamily. Arf family.Protein type: G protein, monomeric; G protein, monomeric, ARFChromosomal Location of Human Ortholog: 1q32.1Cellular Component: cytoplasm; lysosomal membrane; membrane; midbody; spindle midzoneMolecular Function: alpha-tubulin binding; beta-tubulin binding; GTP binding; protein bindingBiological Process: chromosome segregation
