The ARSI Polyclonal Antibody (PACO00430) is a valuable tool for researchers studying ARSI, a gene involved in the regulation of immune responses and inflammation. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in various applications, including Western blotting.ARSI, also known as Arylsulfatase I, plays a critical role in modulating immune function and has been implicated in the pathogenesis of autoimmune diseases and chronic inflammatory conditions.
By targeting ARSI with this antibody, researchers can gain insights into its function and potential therapeutic targets for various diseases.Overall, the ARSI Polyclonal Antibody (PACO00430) is an essential tool for studies in immunology, autoimmune disorders, and inflammation research, allowing for the detection and analysis of ARSI protein expression in different cell types and tissues.
Antibody Name:
ARSI Antibody
Antibody SKU:
PACO00430
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Monkey
Immunogen:
synthesized peptide derived from the Internal region of human Arylsulfatase I.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ARSI; Arylsulfatase I; ASI
UniProt Protein Function:
ARSI: Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. Belongs to the sulfatase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; Hydrolase; Secreted; Calcium-binding; EC 3.1.6.-Chromosomal Location of Human Ortholog: 5q32Cellular Component: endoplasmic reticulum lumen; extracellular regionMolecular Function: arylsulfatase activity; metal ion binding; protein bindingBiological Process: cellular protein metabolic process; glycosphingolipid metabolic process; post-translational protein modification; sphingolipid metabolic process
UniProt Protein Details:
NCBI Summary:
Sulfatases (EC 3.1.5.6), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
