The ARSK Polyclonal Antibody (PAC015561) is a crucial tool for researchers studying ARSK, a key enzyme involved in the metabolism of arylsulfatase substrates. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blotting.ARSK, a member of the arylsulfatase family, plays a vital role in catalyzing the desulfation of sulfated compounds, which is essential for various biological processes including hormone regulation and cellular metabolism.
Dysregulation of ARSK has been linked to diseases such as cancer and metabolic disorders, making it a promising target for therapeutic interventions.The ARSK Polyclonal Antibody enables precise detection and quantification of ARSK protein levels in different cell types, facilitating research in areas such as oncology and metabolic diseases. Understanding the functions and regulatory mechanisms of ARSK is crucial for developing targeted treatments and diagnostic tools for related health conditions.
Antibody Name:
ARSK Antibody (PACO15561)
Antibody SKU:
PACO15561
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human ARSK
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15561(ARSK Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO15561(ARSK Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules.
Synonyms:
arylsulfatase family, member K
UniProt Protein Function:
ARSK: Belongs to the sulfatase familyProtein type: EC 3.1.6.-; Secreted, signal peptide; Secreted; HydrolaseChromosomal Location of Human Ortholog: 5q15Cellular Component: endoplasmic reticulum lumen; extracellular regionMolecular Function: arylsulfatase activity; metal ion bindingBiological Process: cellular protein metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; post-translational protein modification
UniProt Protein Details:
NCBI Summary:
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
