The ASIP Polyclonal Antibody (CAB13280) is a powerful tool for researchers studying the ASIP (Agouti Signaling Protein) protein, which plays a key role in regulating melanin production and skin pigmentation. This antibody, raised in rabbits, has been validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.ASIP is a critical regulator of melanogenesis, the process by which melanin is produced and distributed in the skin. Dysregulation of ASIP has been linked to skin pigmentation disorders, such as vitiligo, as well as to melanoma, a dangerous form of skin cancer. By targeting ASIP with this antibody, researchers can explore the mechanisms underlying these conditions and develop targeted therapies for melanin-related disorders.
With its high reactivity and specificity for human samples, the ASIP Polyclonal Antibody is a valuable tool for furthering our understanding of skin pigmentation and melanogenesis, as well as for identifying potential therapeutic targets for melanin-related disorders. Whether in basic research or clinical studies, this antibody enables precise detection and analysis of ASIP in various cell types, making it indispensable for studies in dermatology, oncology, and immunology.
Product Name:
ASIP Rabbit Polyclonal Antibody
SKU:
CAB13280
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2).
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
Purification Method:
Affinity purification
Gene ID:
434
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of HeLa cells using ASIP antibody (CAB13280). Blue: DAPI for nuclear staining.
