Description
AVPR2 Antibody (CAB7879)
The AVPR2 Antibody (CAB7879) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific to human AVPR2 and has been validated for use in Western blot applications.AVPR2 is known for its role in the regulation of water balance in the body, making it an important target for studies in physiology, nephrology, and endocrinology. Dysregulation of AVPR2 function has been linked to various conditions including diabetes insipidus and other water balance disorders, making this antibody a valuable asset for research in these areas.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
| Product Name: | AVPR2 Antibody |
| SKU: | CAB7879 |
| Size: | 20μL, 100μL |
| Reactivity: | Human |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||
| Sequence: | IHAS LVPG PSER PGGR RRGR RTGS PGEG AHVS AAVA KTVR MTLV IVVV YVLC WAPF FLVQ LWAA WDPE APLE GAPF VLLM LLAS LNSC TNPW IYAS FSSS VSSE LRSL LCCA RGRT PPSL GPQD ESCT TASS SLAK DTSS | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | DI1, DIR, NDI, V2R, ADHR, DIR3, NDI1, AVPR2 |
| Positive Sample: | 293T, COS-1 |
| Cellular Localization: | Cell Membrane, Multi-Pass Membrane Protein. |
| Calculated MW: | 40kDa |
| Observed MW: | 46kDa |
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.
| Purification Method | Affinity purification |
| Gene ID | 554 |
| RRID | AB_2768530 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of various lysates using AVPR2 Rabbit pAb (CAB7879) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s. |
