The B3GALT2 Polyclonal Antibody (PACO05611) is a valuable tool for researchers studying B3GALT2, an enzyme involved in glycosylation processes. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for various applications such as Western blotting.B3GALT2 is essential for the biosynthesis of glycosaminoglycans, which are important components of the extracellular matrix and play a critical role in cell adhesion, signaling, and migration. Dysregulation of B3GALT2 expression has been linked to various diseases, including cancer and developmental disorders.
Therefore, studying the expression and function of B3GALT2 using this antibody can provide valuable insights into its role in these pathological conditions.By targeting B3GALT2 with the PACO05611 antibody, researchers can investigate the mechanisms underlying glycosylation processes and their impact on cellular functions. This antibody is a valuable resource for studies in glycobiology, cancer biology, and developmental biology, offering a deeper understanding of the intricate molecular processes driving disease progression.
Antibody Name:
B3GALT2 Antibody (PACO05611)
Antibody SKU:
PACO05611
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
ELISA:1:40000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the C-terminal region of human β -1,3-Gal-T2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.
NCBI Summary:
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]
