The BCAS4 Polyclonal Antibody (PAC019345) is a valuable tool for researchers studying BCAS4, a protein involved in breast cancer and metastasis. This antibody is generated in rabbits and demonstrates high reactivity with human samples, making it suitable for Western blot applications. By binding specifically to BCAS4, this antibody facilitates the detection and analysis of the protein in various cell types, making it well-suited for studies in oncology and cancer research.BCAS4, also known as Breast Carcinoma Amplified Sequence 4, is a promising target for understanding the mechanisms underlying breast cancer progression and metastasis.
Studies have shown that BCAS4 plays a role in promoting tumor growth and invasion, making it a potential therapeutic target for the development of targeted treatments for breast cancer patients. By elucidating the function of BCAS4, researchers can uncover new insights into breast cancer biology and potentially identify novel treatment strategies for this disease.
Antibody Name:
BCAS4 Antibody (PACO19345)
Antibody SKU:
PACO19345
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human BCAS4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19345(BCAS4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The gene encoding BCAS4 (Breast carcinoma-amplified sequence 4), a 211 amino acid, protein, is found in a region on chromosome 20 that is frequently amplified in human breast cancer. This 20q13 locus amplification is found in 12%–39% of primary breast tumors, which correlates with a 17q23 locus amplification that is found in 20% of primary breast tumors. The amplification and translocation between the BCAS4 gene and the BCAS3 gene, with a 17q23 locus, results in a fusion transcript that is overexpressed in MCF-7 cells. Also, deletion of chromosomal region 20q13.13-q13.2 and resultant deletion of BCAS4, as well as three other genes, is the cause of Okihiro syndrome, a disease characterized by ocular and upper limb anomalies. BCAS4 is normally expressed in thymus, kidney, spleen, placenta and brain. There are three isoforms of BCAS4 which are produced as a result of alternative splicing events.
Synonyms:
breast carcinoma amplified sequence 4
UniProt Protein Function:
BCAS4: A chromosomal aberration involving BCAS4 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS3. Belongs to the cappuccino family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: OncoproteinChromosomal Location of Human Ortholog: 20q13.13Biological Process: intracellular transport
