The BCAS4 Polyclonal Antibody (PAC019346) is a valuable tool for researchers studying BCAS4, a protein correlated with breast cancer progression and metastasis. This antibody, produced in rabbits, exhibits high specificity and sensitivity when used in Western blotting applications with human samples. By targeting the BCAS4 protein, researchers can accurately detect and analyze its expression in various cell types, making it a valuable asset for investigations in oncology.BCAS4, also known as Breast Carcinoma Amplified Sequence 4, is associated with aggressive behavior in breast cancer cells and is implicated in the promotion of tumor growth and spread.
Its role in cancer progression makes it a promising target for the development of novel therapeutics and prognostic markers. By studying BCAS4 expression and function, researchers can gain insights into the mechanisms driving breast cancer development and identify potential targets for treatment strategies.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19346(BCAS4 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse spleen tissue, Primary antibody: PACO19346(BCAS4 Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second.
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19346(BCAS4 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The gene encoding BCAS4 (Breast carcinoma-amplified sequence 4), a 211 amino acid, protein, is found in a region on chromosome 20 that is frequently amplified in human breast cancer. The amplification and translocation between the BCAS4 gene and the BCAS3 gene, with a 17q23 locus, results in a fusion transcript that is overexpressed in MCF-7 cells. Also, deletion of chromosomal region 20q13.13-q13.2 and resultant deletion of BCAS4, as well as three other genes, is the cause of Okihiro syndrome, a disease characterized by ocular and upper limb anomalies.
Synonyms:
breast carcinoma amplified sequence 4
UniProt Protein Function:
BCAS4: A chromosomal aberration involving BCAS4 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS3. Belongs to the cappuccino family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: OncoproteinChromosomal Location of Human Ortholog: 20q13.13Biological Process: intracellular transport
