Description
Bcl-2 Monoclonal Antibody (CAB20736)
The BCL-2 Monoclonal Antibody (CAB20736) is a valuable tool for researchers studying the B-cell lymphoma 2 (BCL-2) protein, a key regulator of apoptosis and cell survival. This antibody, developed specifically for use in immunohistochemistry (IHC) and western blot applications, is highly specific to human samples.The BCL-2 protein plays a critical role in regulating programmed cell death, making it an important target for research in cancer biology and drug development. Dysregulation of BCL-2 expression is associated with various cancers, including lymphoma, leukemia, and solid tumors, making it a promising therapeutic target.
By using the BCL-2 Monoclonal Antibody, researchers can accurately detect and analyze BCL-2 expression in tissue samples, providing valuable insights into the role of this protein in cancer progression and treatment response. This antibody is a valuable tool for advancing research in oncology and developing targeted therapies for BCL-2-associated malignancies.
| Product Name: | Bcl-2 Monoclonal Antibody |
| Product Code: | CAB20736 |
| Reactivity: | Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC50821 |
| Reactivity: | Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | NIH/3T3, Mouse spleen, Rat thymus |
| Cellular Location: | Endoplasmic reticulum membrane, Mitochondrion outer membrane, Nucleus membrane, Single-pass membrane protein |
| Customer Validation: | WB(Mus musculus, Rattus norvegicus) |
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bcl-2 (NP_000624.2) |
| Sequence: | MAHAG RTGYD NREIV MKYIH YKLSQ RGYEW DAGDV GAAPP GAAPA PGIFS SQPGH TPHPA ASRDP VARTS PLQTP AAPGA AAGPA LSPVP PVVHL TLRQA |
| Synonyms: | Bcl-2, PPP1R50 |
| Calculated MW: | 26kDa |
| Observed MW: | 24kDa |
